centrosomal protein 4; centrosomal protein of 135 kDa; Cep135 (CEP135, CEP4, KIAA0635)

Function

• centrosomal protein involved in centriole biogenesis
• acts as a scaffolding protein during early centriole biogenesis
• also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole
• interacts with DCTN2 (putative)
• interacts with CEP250

Structure

belongs to the CEP135/TSGA10 family

Compartment

• cytoplasm, cytoskeleton, centrosome, centriole
• during centriole biogenesis, concentrated within the proximal lumen of both parental centrioles & procentrioles

Alternative splicing

named isoforms=2

More general terms

• centrosomal protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9662
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9662
• OMIM: https://mirror.omim.org/entry/611423
• UniProt: http://www.uniprot.org/uniprot/Q66GS9.html