ubiquitin carboxyl-terminal hydrolase 17-like protein 6 (ubiquitin thioesterase 17-like protein 6, ubiquitin-specific-processing protease 17-like protein 6, deubiquitinating enzyme 17-like protein 6, USP17L6, USP17C, USP17D, USP17N)

Function

• seems to be non-functional in the regulation of apoptosis
• cleaves ubiquitin fusion protein substrates

ubiquitin C-terminal thioester + H2O <--> ubiquitin + a thiol

Structure

belongs to the peptidase C19 family, USP17 subfamily

Compartment

nucleus, cytoplasm

Notes

• the RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a copy of USP17
• it is present with an interindividual variation in copy number & between 20 to 103 copies can be found in the genome both on chromosome 4 & chromosome 8

More general terms

• ubiquitin C-terminal hydrolase
• nuclear protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q6QN14.html