ubiquitin carboxyl-terminal hydrolase 17-like protein 3 (ubiquitin thioesterase 17-like protein 3, ubiquitin-specific-processing protease 17-like protein 3, deubiquitinating enzyme 17-like protein 3, USP17L3, USP17B, USP17F)

Function

• role in cell apoptosis
• cleaves ubiquitin fusion protein substrates (putative)

ubiquitin C-terminal thioester + H2O <--> ubiquitin + a thiol

Structure

belongs to the peptidase C19 family, USP17 subfamily

Compartment

nucleus (putative)

Notes

• the RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a copy of USP17
• it is present with an interindividual variation in copy number & between 20 to 103 copies can be found in the genome both on chromosome 4 & chromosome 8

More general terms

• ubiquitin C-terminal hydrolase
• nuclear protein

Database

• UniProt: http://www.uniprot.org/uniprot/A6NCW0.html