Ran guanine nucleotide release factor (RanGNRF, Ran-binding protein MOG1, RANGRF, MOG1, RANGNRF, HSPC165, HSPC236, MDS5)

Function

• may regulate the intracellular trafficking of RAN
• in cardiac cells seems to regulate the cell surface localization of SCN5A

Structure

• monomer (putative)
• interacts with RAN, RAN-GTP & RAN-GDP
• forms a complex with RAN-GTP & RANBP1 (putative)
• interacts with the cytoplasmic loop 2 of SCN5A belongs to the MOG1 family

Compartment

• nucleus, cytoplasm
• shuttles between the nucleus & cytoplasm

Alternative splicing

named isoforms=4

Expression

isoforms 1 & 2 are ubiquitously expressed

More general terms

• nuclear protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2909
• OMIM: https://mirror.omim.org/entry/607954
• UniProt: http://www.uniprot.org/uniprot/Q9HD47.html