flap endonuclease GEN homolog 1 (GEN1)

Function

• endonuclease which cleaves flap structures at the junction between single-stranded DNA & double-stranded DNA
• specific for 5'-overhanging flap structures in which the 5'-upstream of the flap is completely double-stranded
• prefers the blocked-flap structures similar to those occurring at replication forks, in which the 5' single-strand overhang of the flap is double-stranded (putative)

Cofactor: binds 2 Mg+2 per subunit (putative)

Structure

• belongs to the XPG/RAD2 endonuclease family, GEN subfamily

Compartment

nucleus (putative)

More general terms

• endonuclease
• nuclear protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q17RS7.html