transcription initiation factor TFIID subunit 7-like (transcription initiation factor TFIID 50 kD subunit, TATA box-binding protein-associated factor 50 kD, RNA polymerase 2 TBP-associated factor subunit Q, cancer/testis antigen 40, CT40, TAF7L, TAF2Q)

Function

• spermatogensis-specific component of DNA-binding general transcription factor complex TFIID (putative)
• TAF7L may replace TAF7 in a spermatogenensis-specific form of TFIID
• role in spermatogenesis (putative) TAF7L may replace TAF7 in a spermatogenensis-specific form of TFIID
• interacts with TBP in a sub-population of cells (pachytene & haploid round spermatids), developmentally regulated through differential intracellular localization of the two proteins
• interacts with TAF1 (putative)

Structure

belongs to the TAF7 family

Compartment

• nucleus (putative), cytoplasm
• cytoplasmic in spermatogonia & early spermatocytes (preleptotene, leptotene, & zygotene)
• translocates into the nuclei of pachytene spermatocytes & round spermatids (putative)

Alternative splicing

named isoforms=3

Expression

testis-specific

More general terms

• nuclear protein
• testis-specific protein

Database

• OMIM: https://mirror.omim.org/entry/300314
• UniProt: http://www.uniprot.org/uniprot/Q5H9L4.html