histone deacetylase complex subunit SAP130 (130 kD Sin3-associated polypeptide, Sin3-associated polypeptide p130, SAP130)

Function

• transcriptional repressor
• may function in the assembly &/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex & other regulatory complexes
• component of a mSin3A corepressor complex
• acetylated (probable)

Structure

• belongs to the SAP130 family
• N-terminus may interact with a transcriptional coactivator
• C-terminus may interact with HDAC-dependent & HDAC- independent corepressors

Compartment

nucleus (putative)

Alternative splicing

named isoforms=2

Expression

expressed in various cancer cell ines

More general terms

• nuclear protein

Additional terms

• histone deacetylase

Component of

• mSin3A corepressor complex

Database

• UniProt: http://www.uniprot.org/uniprot/Q9H0E3.html