meiotic recombination protein SPO11 (SPO11)

Function

• required for meiotic recombination
• mediates DNA cleavage that forms double-strand breaks that initiate meiotic recombination

Structure

belongs to the TOP6A family

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

highly expressed in testis

More general terms

• nuclear protein
• endodeoxyribonuclease

Database

• OMIM: https://mirror.omim.org/entry/605114
• UniProt: http://www.uniprot.org/uniprot/Q9Y5K1.html