structural maintenance of chromosome 1-like 2 protein; SMC1beta protein (SMC1L2, SMC1B)

Function

• meiosis-specific component of cohesin complex
  • alternate for SMC1L1
• contributes to axial element formation & the organization of chromatin loops along the axial element
• role in synapsis, recombination & chromosome movements
• forms a heterodimer with SMC3

Structure

• flexible hinge domain
  • separates the large intramolecular coiled coil regions
  • allows the heterotypic interaction with the corresponding domain of SMC3, forming a V-shaped heterodimer
    • the 2 heads of the heterodimer are then connected by different ends of the cleavable RAD21 or REC8 protein, forming a ring structure
• belongs to the SMC family. SMC1 subfamily

Compartment

nucleus, associates with chromatin

More general terms

• nuclear protein
• protein subunit

Component of

• cohesin complex

Database

• OMIM: https://mirror.omim.org/entry/608685
• UniProt: http://www.uniprot.org/uniprot/Q8NDV3.html