bromodomain testis-specific protein (RING3-like protein, BRDT)

Function

• role in the transcriptional regulation of spermatogenesis
• structural ATP-independent role in the reorganization of acetylated chromatin
• interacts with histone H4 acetylated N-terminus via 2 bromodomains

Structure

• contains 2 bromo domains

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

testis-specific, adult testis > embryo testis

Pathology

• lack of expression may be correlated with male infertility

More general terms

• nuclear protein
• testis-specific protein

Database

• OMIM: https://mirror.omim.org/entry/602144
• UniProt: http://www.uniprot.org/uniprot/Q58F21.html