synaptonemal complex protein 3 (SCP-3, SYCP3, SCP3)

Function

• component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase
• meiotic function in spermatogenesis
• testis development
• interacts with SYCP2

Compartment

• nucleus
• in tripartite segments of synaptonemal complexes

Expression

testis-specific

Pathology

• defects in SYCP3 are associated with azoospermia due to perturbations of meiosis

More general terms

• nuclear protein
• testis-specific protein

Database

• OMIM: https://mirror.omim.org/entry/270960
• OMIM: https://mirror.omim.org/entry/604759
• UniProt: http://www.uniprot.org/uniprot/Q8IZU3.html