sestrin-1 (p53-regulated protein PA26, SESN1, PA26, SEST1)

Function

• unkonwn
• potential regulator of cellular growth
• isoforms T2 & T3 are induced by genotoxic stress (UV, gamma-irradiation, cytotoxic drugs) {p53-dependent}; isoform T1 is not

Compartment

nucleus

Alternative splicing

named isoforms=3

Expression

widely expressed

Pathology

• defects in SESN1 may be involved in heterotaxia

More general terms

• sestrin
• nuclear protein

Database

• OMIM: https://mirror.omim.org/entry/606103
• UniProt: http://www.uniprot.org/uniprot/Q9Y6P5.html