K+ channel tetramerization domain containing protein 13; BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1; hBACURD1; BTB/POZ domain-containing protein KCTD13; polymerase delta-interacting protein 1; TNFAIP1-like protein (KCTD13, BACURD1, PDIP1, POLDIP1, FKSG86, PP6832)

Function

• substrate-specific adapter of BCR E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure
• protein modification; protein ubiquitination
• component of the BCR(BACURD1) E3 ubiquitin ligase complex
• interacts with RHOA; with a preferrence for RhoA-GDP
• interacts with DNA polymerase delta (POLD2) & PCNA

Structure

• belongs to the BACURD family
• contains 1 BTB/POZ domain

Compartment

nucleus

Expression

• expressed in a wide variety of tissues
• induced by TNF & IL6

More general terms

• nuclear protein

Component of

• BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (KLHL20)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=253980
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:253980
• OMIM: https://mirror.omim.org/entry/608947
• UniProt: http://www.uniprot.org/uniprot/Q8WZ19.html