nucleolar protein family A member 1; H/ACA ribonucleoprotein complex subunit 1; nucleolar protein family A member 1; snoRNP protein GAR1 (GAR1, NOLA1)

Function

• required for ribosome biogenesis & telomere maintenance
• component of H/ACA small nucleolar ribonucleoprotein complex, which catalyzes pseudouridylation of rRNA
• may also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme
• associates with NOLC1/NOPP140
• H/ACA snoRNPs interact with the SMN complex
  • this is mediated by interaction between GAR1 & SMN1 or SMN2
• component of the telomerase holoenzyme complex

Structure

• interaction with SMN1 requires at least one of the RGG-box regions
• belongs to the GAR1 family

Compartment

nucleus, nucleolus, Cajal body

Alternative splicing

named isoforms=2

More general terms

• nuclear protein
• protein subunit

Component of

• H/ACA small nucleolar ribonucleoprotein complex (H/ACA snoRNP complex)
• telomerase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54433
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:54433
• OMIM: https://mirror.omim.org/entry/606468
• UniProt: http://www.uniprot.org/uniprot/Q9NY12.html