pseudouridine (psi uridine)

Introduction

Struture:

• modified nucleotide found in rRNA
• formed via isomerization of uridine catalyzed by the H/ACA snoRNP complex such that ribose is subsequently attached to C5, instead of the normal N1.
• each rRNA can contain up to 100 pseudouridine residues, which may serve to stabilize the conformation of rRNAs.

Laboratory

• pseudouridine in CSF
• pseudouridine in serum/plasma
• pseudouridine/creatinine in urine

More general terms

• ribonucleoside
• pyrimidine nucleoside

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=1177
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=294335