ubiquilin-4; ataxin-1 ubiquitin-like-interacting protein A1U (UBQLN4, C1orf6, UBIN)

Function

• phosphorylated upon DNA damage, probably by ATM or ATR
• homodimer.
• binds SCA1
• binds signal sequences of proteins that are targeted to the endoplasmic reticulum (putative)

Structure

• contains 1 UBA domain
• contains 1 ubiquitin-like domain

Compartment

• nucleus, cytoplasm
• may associate with the endoplasmic reticulum

Expression

• highly expressed in pancreas, kidney, skeletal muscle, heart & throughout the brain
• expressed at lower levels in placenta, lung & liver

More general terms

• ubiquilin
• nuclear protein
• oligomerizing protein
• phosphoprotein

Additional terms

• ubiquitin (UBCEP2, UBB, UBC)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=56893
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:56893
• OMIM: https://mirror.omim.org/entry/605440
• UniProt: http://www.uniprot.org/uniprot/Q9NRR5.html