Sjoegren syndrome/scleroderma autoantigen 1; autoantigen p27 (SSSCA1)

Function

• might play a role in mitosis
• could be a centromere-associated protein
• phosphorylated upon DNA damage, probably by ATM or ATR

Pathology

• antigenic molecule
• may induce anti-centromere antibodies
• autoantibodies against SSSCA1 found in Sjogren's syndrome & scleroderma

More general terms

• nuclear protein
• phosphoprotein

Additional terms

• scleroderma (diffuse cutaneous systemic sclerosis)
• Sjogren's syndrome (autoimmune epitheliitis)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10534
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10534
• OMIM: https://mirror.omim.org/entry/606044
• UniProt: http://www.uniprot.org/uniprot/O60232.html