SNF-related serine/threonine protein kinase; SNF1-related kinase (SNRK, KIAA0096, SNFRK)

Function

(postulated)

• hematopoietic cell proliferation/differentiation
• neuronal apoptosis
• activated by phosphorylation on Thr-173 by STK11/LKB1 in complex with STRADA pseudo kinase & CAB39
• autophosphorylated

Cofactor: Mg+2

Structure

• belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family
• contains 1 protein kinase domain
• contains 1 UBA domain

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

• expressed in hematopoietic progenitor cells, leukemic cell lines > testis

More general terms

• serine/threonine kinase
• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54861
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:54861
• OMIM: https://mirror.omim.org/entry/612760
• UniProt: http://www.uniprot.org/uniprot/Q9NRH2.html