ribosomal protein S6 kinase delta-1; S6K-delta-1; 52 kD ribosomal protein S6 kinase; ribosomal S6 kinase-like protein with two PSK domains 118 kD protein; SPHK1-binding protein (RPS6KC1, RPK118)

Function

• transmits sphingosine-1 phosphate signal
• interacts with SPHK1 & phosphatidylinositol 3-phosphate

Structure

• 1st kinase domain appears to be pseudokinase domain
• belongs to the protein kinase superfamily, Ser/Thr protein kinase family, S6 kinase subfamily
• contains 1 MIT domain
• contains 2 protein kinase domains
• contains 1 PX (phox homology) domain

Compartment

cytoplasm, membrane-associated, early endosomes

Expression

• expressed in testis, skeletal muscle, brain, heart, placenta, kidney, liver > thymus, small intestine, lung, colon

More general terms

• ribosomal protein S6 kinase
• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26750
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:26750
• UniProt: http://www.uniprot.org/uniprot/Q96S38.html