serine/threonine protein kinase TNNI3K; TNNI3-interacting kinase; cardiac ankyrin repeat kinase (TNNI3K, CARK)

Function

• may play a role in cardiac physiology
• autophosphorylated
• interacts with TNNI3, ACTC, ACTA1, MYBPC3, AIP, BABP3 & HADHB

Cofactor: Mg+2

Structure

• belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
• contains 10 ANK repeats
• contains 1 protein kinase domain

Compartment

• nucleus, cytoplasm
• expressed at lower levels in the cytoplasm

Alternative splicing

named isoforms=4

Expression

• highly expressed in both adult & fetal heart

More general terms

• serine/threonine kinase
• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=100526
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51086
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:100526
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51086
• OMIM: https://mirror.omim.org/entry/613932
• UniProt: http://www.uniprot.org/uniprot/Q59H18.html