trifunctional enzyme beta subunit, mitochondrial; TP-beta; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase beta subunit (HADHB)

Function

• lipid metabolism; fatty acid beta-oxidation
• octamer of 4 alpha (HADHA) & 4 beta (HADHB) subunits
• interacts with RSAD2/viperin

Structure

belongs to the thiolase family

Compartment

• mitochondria
• endoplasmic reticulum

Alternative splicing

named isoforms=2

Pathology

• defects in HADHB are a component of trifunctional protein deficiency

More general terms

• protein subunit
• mitochondrial protein
• dehydrogenase

Component of

• mitochondrial trifunctional enzyme complex (trifunctional protein complex, TFP complex, trifunctional enzyme)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3032
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3032
• OMIM: https://mirror.omim.org/entry/143450
• OMIM: https://mirror.omim.org/entry/609015
• UniProt: http://www.uniprot.org/uniprot/P55084.html