survival of motor neuron protein-interacting protein 1; SMN-interacting protein 1; component of gems 2; Gemin-2 (SIP1, GEMIN2)

Function

• forms complex with survival motor neuron protein-1
• component of the core SMN complex
• interacts directly with GEMIN5

Structure

belongs to the gemin-2 family

Compartment

• nucleus, gem, cytoplasm
• localized in subnuclear structures next to coiled bodies, called gems, which are highly enriched in spliceosomal snRNPs
• also found in the cytoplasm

Alternative splicing

named isoforms=4

Notes

uncertain whether Met-1 or Met-12 is the initiator

More general terms

• nuclear protein
• phosphoprotein

Additional terms

• survival motor neuron protein-1; component of gems 1; Gemin-1 (SMN1, SMN, SMNT, SMN2, SMNC)

Component of

• SMN complex
• import snRNP complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8487
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8487
• OMIM: https://mirror.omim.org/entry/602595
• UniProt: http://www.uniprot.org/uniprot/O14893.html