proline-rich acidic protein 1 (uterine-specific proline-rich acidic protein, PRAP1, UPA, UNQ608/PRO1195)

Function

• may play an important role in maintaining normal growth homeostasis in epithelial cells

Compartment

secreted

Alternative splicing

named isoforms=4

Expression

• abundantly expressed in epithelial cells of liver, kidney, gastrointestinal tract & cervix
• up-regulated by butyrate, trichostatin A & 5'-aza-2' deoxycytidine

Pathology

• significantly down-regulated in hepatocellular carcinoma & right colon adenocarcinoma compared with the respective adjacent normal tissues

More general terms

• secreted protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q96NZ9.html