gastrokine-1; 18 kD antrum mucosa protein; AMP-18; protein CA11 (GKN1, AMP18, CA11, UNQ489/PRO1005)

Function

• mitogenic activity
• maintenance of gastric mucosal epithelium

Structure

• belongs to the gastrokine family,
• contains 1 BRICHOS domain

Compartment

secreted

Expression

• expressed in stomach
• no expression in gastric cancer tissue or gastric cancer cell lines

Notes

• uncertain whether Met-1 or Met-15 is the initiator

More general terms

• secreted protein

Additional terms

• gastrokine-2 (blottin, Trefoil factor interactions(z) 1, down-regulated in gastric cancer, GKN2, BLOT, GDDR, TFIZ1, UNQ465/PRO813)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=56287
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:56287
• OMIM: https://mirror.omim.org/entry/606402
• UniProt: http://www.uniprot.org/uniprot/Q9NS71.html