beta-microseminoprotein; immunoglobulin-binding factor; IGBF; PN44; prostate secreted seminal plasma protein; prostate secretory protein of 94 amino acids; PSP-94; PSP94; seminal plasma beta-inhibin (MSMB, PRSP)

Function

• interacts with PI16
• specific receptors for MSMB are found on spermatozoa & in the prostate

Structure

• homodimer
• belongs to the beta-microseminoprotein family

Compartment

secreted, sperm surface

Alternative splicing

named isoforms=2; PSP94, PSP57

Expression

• strongly expressed in prostate, liver, kidney, breast & penis
• also expressed in pancreas, esophagus, stomach, duodenum, colon, trachea, lung, salivary glands & fallopian tube
• PSP94 is expressed in lung & breast
• PSP57 is found in kidney & bladder

Pathology

• defects in MSMB are the cause of susceptibility to prostate cancer hereditary type 13

Notes

• originally thought to inhibit the secretion of FSH by pituitary cells

More general terms

• secreted protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4477
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4477
• OMIM: https://mirror.omim.org/entry/157145
• OMIM: https://mirror.omim.org/entry/611928
• UniProt: http://www.uniprot.org/uniprot/P08118.html