CD179b; immunoglobulin lambda-like polypeptide 1; CD179 antigen-like family member B; Ig lambda-5; immunoglobulin omega polypeptide; immunoglobulin-related protein 14.1 (IGLL1, IGL1)

Function

• critical for B-cell development
• associates non-covalently with VPREB1

Structure

• contains 1 Ig-like C1-type (immunoglobulin-like) domain

Compartment

secreted

Alternative splicing

named isoforms=2

Expression

• expressed only in pre-B-cells & a special B-cell line (which is surface Ig negative)

Pathology

• defects in IGLL1 are the cause of agammaglobulinemia type 2

More general terms

• secreted protein
• CD antigen

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3543
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3543
• OMIM: https://mirror.omim.org/entry/146770
• OMIM: https://mirror.omim.org/entry/613500
• UniProt: http://www.uniprot.org/uniprot/P15814.html