K+ voltage-gated channel subfamily V member 1 (voltage-gated K+ channel subunit Kv8.1, neuronal K+ channel alpha subunit HNKA, KCNV1)

Function

• K+ channel subunit
• does not form functional channels by itself
• modulates KCNB1 & KCNB2 channel activity by shifting threshold for inactivation to more negative values & by slowing the rate of inactivation
• can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 & KCND1, possibly by trapping them in intracellular membranes
• heteromultimer with KCNB1 & KCNB2
• interacts with KCNC4 & KCND1

Structure

• segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every third position (putative)
• belongs to the K+ channel family V subfamily

Compartment

• cell membrane
• association with another K+ channel subunit required for insertion in the plasma membrane (remains intracellular in the absence of KCNB2)

Expression

detected in brain

More general terms

• transmembrane 6 protein
• K+ channel subfamily V
• protein subunit

Database

• OMIM: https://mirror.omim.org/entry/608164
• UniProt: http://www.uniprot.org/uniprot/Q6PIU1.html