coagulation factor VIII heavy chain

Introduction

Two chains of factor VIII derived from proteolysis of common precursor. N-terminal cleavage product. Contains domain(s) homologous to factor V & to ceruloplasmin.

More general terms

• protein subunit

Component of

• coagulation factor VIII; antihemophilic factor; AHF; procoagulant component; contains: factor VIIIa heavy chain, 200 kD & 92 isoforms; factor VIII B chain; factor VIIIa light chain (F8, F8C)