interleukin-23 subunit alpha; IL-23 subunit alpha; IL-23-A; interleukin-23 subunit p19; IL-23p19 (IL23A, SGRF, UNQ2498/PRO5798)

Function

• associates with IL12B to form IL-23 interleukin

Structure

• belongs to the IL-6 superfamily
• heterodimer with IL12B, disulfide-linked (IL-23)

Compartment

• secreted
• secreted upon association with IL12B

Expression

• secreted by activated dendritic & phagocytic cells & keratinocytes
• expressed by dermal Langerhans cells
• expressed by newborns dendritic cells
• up-regulated by a wide array of pathogens & pathogen-products together with self-signals for danger or injury

Pathology

• up-regulated in psoriatic dermal tissues, in dendritic cells of multiple sclerosis patients & in tumors

More general terms

• protein subunit

Component of

• interleukin-23 (IL23)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51561
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51561
• OMIM: https://mirror.omim.org/entry/605580
• UniProt: http://www.uniprot.org/uniprot/Q9NPF7.html