serine/threonine protein phosphatase 4 regulatory subunit 1 (PPP4R1, PP4R1, MEG1)

Function

• regulatory subunit of protein phosphatase 4
• may play a role in regulation of cell division in renal glomeruli
• the PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation & regulation of HDAC3
• component of the PP4 complex PPP4C-PPP4R1
• interacts with HDAC3

Structure

contains 14 HEAT repeats

Alternative splicing

named isoforms=2

Expression

• widely expressed with high expression in cultured mesangial cells
• isoform 1 & isoform 2 are expressed in renal tissues

More general terms

• enzyme regulatory subunit

Additional terms

• serine/threonine protein phosphatase 4 regulatory subunit 1-like (PRO1085, PPP4R1L, C20orf192)

Component of

• serine/threonine protein phosphatase 4 (PP4)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9989
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9989
• OMIM: https://mirror.omim.org/entry/604908
• UniProt: http://www.uniprot.org/uniprot/Q8TF05.html