Na+/K+ ATPase-gamma (FXYD domain-containing ion transport regulator 2, FXYD2, ATP1C, ATP1G1)

Function

• may play role in forming the receptor site for cardiac glycoside binding
• may modulate the transport function of the Na+/K+ ATPase

Structure

belongs to the FXYD family

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

• expressed in the distal convoluted tubule of kidney
• found on basolateral membranes of nephron epithelial cells

Pathology

• defects in FXYD2 are a cause of renal hypomagnesemia 2

More general terms

• protein subunit
• plasma membrane protein

Component of

• Na+/K+ ATPase

Database

• OMIM: https://mirror.omim.org/entry/154020
• OMIM: https://mirror.omim.org/entry/601814
• UniProt: http://www.uniprot.org/uniprot/P54710.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=486