anaphase promoting complex subunit 11; hepatocellular carcinoma associated ring finger protein; protein HSPC214 (ANAPC11)

Function

• component of the anaphase promoting complex/cyclosome (APC/C)
• may recruit the E2 ubiquitin-conjugating enzymes to APC/C
• interacts with the cullin domain of ANAPC2
• interacts with UBE2D2

Structure

• RING-type Zn+2 finger domain coordinates an additional 3rd Zn+2
• belongs to the RING-box family
• contains 1 RING-type Zn+2 finger

Compartment

cytoplasm, nucleus

Alternative splicing

named isoforms=2

Expression

• expressed in skeletal muscle & hear > brain, kidney, & liver > colon, thymus, spleen, small intestine, placenta, lung & peripheral blood leukocyte

More general terms

• ring finger protein
• protein subunit

Component of

• anaphase promoting complex (APC, cyclosome)

Database

• UniProt: http://www.uniprot.org/uniprot/Q9NYG5.html