splicing factor 3A subunit 1 (spliceosome associated protein 114, SAP 114, SF3a120, SF3A1)

Function

• subunit of the splicing factor SF3A
• identified in the spliceosome C complex
• interacts with SF3A3
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• contains 2 SURP motif repeats
• contains 1 ubiquitin-like domain

Compartment

nucleus (putative)

Expression

ubiquitously expressed

More general terms

• splicing factor; snRNP-associated protein
• protein subunit

Component of

• splicing factor 3A (SF3A)
• spliceosome C complex

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1029
• OMIM: https://mirror.omim.org/entry/605595
• UniProt: http://www.uniprot.org/uniprot/Q15459.html