origin recognition complex subunit 3; origin recognition complex subunit Latheo (ORC3L, ORC3)

Function

• component of the origin recognition complex (ORC) that binds origins of replication
• role in both chromosomal replication & mating type transcriptional silencing
• binds to the ARS consensus sequence of origins of replication (ATP-dependent)
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

belongs to the ORC3 family

Compartment

nucleus

Alternative splicing

named isoforms=2

More general terms

• protein subunit

Component of

• origin of replication complex (origin recognition complex, ORC)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2359
• OMIM: https://mirror.omim.org/entry/604972
• UniProt: http://www.uniprot.org/uniprot/Q9UBD5.html