prefoldin subunit 6; protein Ke2 (PFDN6)

Function

• binds specifically to cytosolic chaperonin (c-CPN) & transfers target proteins to it
• binds to nascent polypeptide chain & promotes folding in an environment in which there are many competing pathways for nonnative proteins
• binds to c-Myc; interacts with its N-terminal domain
• represses the transcriptional activity of c-Myc

Structure

belongs to the prefoldin subunit alpha family

Expression

• expressed in pancreas & skeletal muscle > other tissues

More general terms

• protein subunit

Component of

• prefoldin

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5204
• OMIM: https://mirror.omim.org/entry/605660
• UniProt: http://www.uniprot.org/uniprot/O15212.html