prefoldin subunit 3 (Von Hippel-Lindau-binding protein 1, VHL-binding protein 1, VBP-1, HIBBJ46PFDN3, VBP1, PFDN3)

Function

• binds specifically to cytosolic chaperonin (c-CPN) & transfers target proteins to it
• binds to nascent polypeptide chain & promotes folding in an environment in which there are many competing pathways for nonnative proteins
• binds to the C-terminal part of VHL

Compartment

• cytoplasm
• in complex with VHL can translocate to the nucleus

Expression

ubiquitous

More general terms

• protein subunit

Additional terms

• von Hippel-Lindau disease

Component of

• prefoldin

Database

• OMIM: https://mirror.omim.org/entry/300133
• UniProt: http://www.uniprot.org/uniprot/P61758.html