complement C1q-beta chain (complement C1q subunit B, C1QB)

Function

• component of complement C1q & thus the complement cascade
• binding site for immunoglobulin binds IgM & IgG subclasses IgG1, IgG2, & IgG3

Structure

• contains 1 C1q domain
• contains 1 collagen-like domain
• O-linked glycans consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups

Compartment

secreted

Pathology

defects in C1QB are a cause of C1q deficiency

More general terms

• protein subunit

Component of

• complement C1q

Database

• UniProt: http://www.uniprot.org/uniprot/P02746.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:713
• OMIM: https://mirror.omim.org/entry/120570