PTB-containing, cubilin & LRP1-interacting protein (P-CLI1, phosphotyrosine interaction domain-containing protein 1, protein NYGGF4, PID1, NYGGF4, PCLI1, HMFN2073)

Function

• increases proliferation of preadipocytes without affecting adipocyte differentiation
• found in a complex with PID1/PCLI1, LRP1 & CUBNI
• interacts with LRP1 & CUBN

Structure

contains 1 PID domain

Alternative splicing

named isoforms=4

Expression

• expressed in subcutaneous fat, heart, skeletal muscle, brain, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung & peripheral blood leukocyte
• up-regulated in fat of obese subjects

Polymorphism

some sequences seem to have a duplication of exon 2

More general terms

• other protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q7Z2X4.html