MIR-interacting saposin-like protein; transmembrane protein 4; secreted protein ZSIG9 (TMEM4, CNPY2, MSAP, ZSIG9, UNQ1943/PRO4426)

Function

• positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC)
• prevents MIR-mediated MRLC ubiquitination & its subsequent proteasomal degradation
• interacts with MYLIP/MIR

Structure

contains 1 saposin B-type domain

Alternative splicing

named isoforms=2

Expression

• expressed in different tissues
• ighest levels in adult placenta, liver, pancreas

More general terms

• other protein

Database

• OMIM: https://mirror.omim.org/entry/605861
• UniProt: http://www.uniprot.org/uniprot/Q9Y2B0.html