suppression of tumorigenicity 5 (HeLa tumor suppression 1, DENN domain-containing protein 2B, ST5, DENND2B, HTS1)

Function

• role in cytoskeletal organization
• isoform 1
  • putative role in activation of MAPK1/ERK2
  • interacts with the SH3 domain of ABL1
• isoform 3
  • may block ERK2 activation stimulated by ABL1
  • may alter cell morphology & cell growth

Structure

• contains 1 dDENN domain contains 1 DENN domain contains 1 uDENN domain

Alternative splicing

• named isoforms=3
• alternative promoter usage

Expression

• widely expressed, except in peripheral blood lymphocytes
• isoform 1 is expressed in several epithelial & fibroblast cell lines
• isoform 3 is expressed in lines

Pathology

• role in tumorgenicity
• isoform 1 is expressed in tumor cell lines
• isoform 3 is not expressed in tumor cell lines

More general terms

• other protein

Database

• OMIM: https://mirror.omim.org/entry/140750
• UniProt: http://www.uniprot.org/uniprot/P78524.html