PDZ domain-containing protein 3 (intestinal & kidney-enriched PDZ protein, protein DLNB27, PDZD3, IKEPP, PDZK2)

Function

• regulatory protein that interacts with the C-terminal region of GUCY2C & negatively modulates its heat-stable enterotoxin- mediated activation
• interacts with SLC34A1

Compartment

• cell membrane, peripheral membrane
• apical surface of intestinal epithelial cells

Alternative splicing

named isoforms=5

Expression

• expressed in kidney, gastrointestinal tract
• not expressed in brain, heart, skeletal muscle or hematopoietic cells

More general terms

• other protein

Additional terms

• PDZ (PSD-95 post-synaptic density protein, Discs large, Zona occludens tight junction protein) domain
• PDZ domain-containing protein

Database

• OMIM: https://mirror.omim.org/entry/607146
• UniProt: http://www.uniprot.org/uniprot/Q86UT5.html