Na+ dependent phosphate transport protein 2A; Na+-phosphate transport protein 2A; Na+ dependent phosphate cotransporter 2A; Na+/phosphate cotransporter 2A; Na+/Pi cotransporter 2A; NaPi-2a; NaPi-3; solute carrier family 34 member 1 (SLC34A1, NPT2)

Function

• role in actively transporting phosphate into cells via Na+ cotransport in the renal brush border membrane (putative)
• probably mediates 70-80% of the apical influx
• interacts via its C-terminal region with PDZK2

Structure

belongs to the SLC34A transporter family

Compartment

membrane

Expression

kidney & lung

Pathology

• defects in SLC34A1 are the cause of hypophosphatemic nephrolithiasis/osteoporosis type 1

More general terms

• transmembrane 8 protein
• Na+/phosphate cotransporter
• solute carrier family 34 (SLC34, SLC34A)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6569
• OMIM: https://mirror.omim.org/entry/182309
• OMIM: https://mirror.omim.org/entry/612286
• UniProt: http://www.uniprot.org/uniprot/Q06495.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6569