protein Chibby; PKD2 interactor; Golgi & endoplasmic reticulum associated 1; PIGEA-14; cytosolic leucine-rich protein (PGEA1, C22orf2, CBY, CBY1, HRIHFB2025)

Function

• inhibits the Wnt/Wingless pathway
  • binds to beta-catenin
  • inhibits beta-catenin-mediated transcriptional activation
  • competes with TCF/LEF transcription factors
• regulates intracellular trafficking of polycystin-2/PKD2

Structure

homodimer

Compartment

nucleus, nuclear speckle, trans-Golgi network

Expression

• widely expressed
• expressed in heart, skeletal muscle, kidney, placenta > brain, lung, liver, testis

Pathology

• down-regulated in thyroid carcinoma & metastatic uterine cancer

Notes

• Chibby is Japanese for 'small'
• the gene was so named for the RNAi phenotype seen in flies

More general terms

• other protein

Database

• OMIM: https://mirror.omim.org/entry/607757
• UniProt: http://www.uniprot.org/uniprot/Q9Y3M2.html