TP53-regulated inhibitor of apoptosis 1 (p53-inducible cell-survival factor, p53CSV, protein 15E1.1, WF-1, TRIAP1, 15E11, HSPC132)

Function

• mediates cell survival by inhibiting activation of caspase-9
• induced in p53-dependent manner in response to low levels of DNA damage
• NOT induced when DNA damage is severe
• interacts with APAF1 & HSP70

Compartment

cytoplasm, perinuclear region

More general terms

• other protein

Database

• UniProt: http://www.uniprot.org/uniprot/O43715.html