GTPase-activating Rap/Ran-GAP domain-like 1; Ral GTPase-activating protein subunit alpha-1; GAP-related-interacting partner to E12; GRIPE; tuberin-like protein 1; p240 (RALGAPA1, GARNL1, KIAA0884, TULIP1)

Function

• catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA & RALB (putative)
• heterodimerization is required for activity
• phosphorylated upon DNA damage, probably by ATM or ATR
• interacts with TCF3 in the developing embryonic forebrain
  • interacts with the HLH region of TCF3/isoform E12
  • transcriptional regulator of genes under control of TCF3
• neuronal differentiation

Structure

contains 1 rap-GAP domain

Compartment

• cytoplasmic
• translocated to nucleus, when associated with TCF3

Alternative splicing

named isoforms=6

Expression

widely expressed

More general terms

• enzyme catalytic subunit
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=253959
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:253959
• OMIM: https://mirror.omim.org/entry/608884
• UniProt: http://www.uniprot.org/uniprot/Q6GYQ0.html