connector enhancer of kinase suppressor of ras 2; connector enhancer of KSR 2; CNK homolog protein 2; CNK2 (CNKSR2, CNK2, KIAA0902, KSR2)

Function

• adapter protein or regulator of Ras signaling pathways
• phosphorylated on Tyr
• interacts with RAF1, RAB2L & RAL GTPase

Structure

• belongs to the CNKSR family
• contains 1 CRIC domain
• contains 1 DUF1170 domain
• contains 1 PDZ domain (DHR domain)
• contains 1 PH domain

Compartment

cytoplasm, membrane

Alternative splicing

named isoforms=4

More general terms

• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=22866
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:22866
• UniProt: http://www.uniprot.org/uniprot/Q8WXI2.html