PX domain-containing protein kinase-like protein; modulator of Na+K+-ATPase; MONaKA (PXK)

Function

• binds to & modulates brain Na+/K+ ATPase subunits ATP1B1 & ATP1B3
• role in regulation of electrical excitability & synaptic transmission
• may not display kinase activity

Structure

• the protein kinase domain is predicted to be catalytically inactive
• belongs to the protein kinase superfamily
• contains 1 protein kinase domain
• contains 1 PX (phox homology) domain
• contains 1 WH2 domain

Compartment

• cytoplasm, cell membrane
• associates with the plasma membrane
• isoform 3 is present throughout the cell

Alternative splicing

named isoforms=7

Expression

• widely expressed in almost all tissues examined
• not expressed in heart
• isoform 1 is highly expressed in brain, skeletal muscle, spleen & testis
• isoform 7 may not be expressed

More general terms

• other protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54899
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:54899
• OMIM: https://mirror.omim.org/entry/611450
• UniProt: http://www.uniprot.org/uniprot/Q7Z7A4.html