Activator of 90 kDa heat shock protein ATPase homolog 1 (AHA1, p38, HSPC322, AHSA1, C14orf3)

Function

• co-chaperone that stimulates HSP90 ATPase activity
• may affect a step in the endoplasmic reticulum to Golgi trafficking
• interacts with HSPCA/HSP90 & with the cytoplasmic tail of the vesicular stomatitis virus glycoprotein (VSV G)
• interacts with GCH1
• interacts with SRPK1

Structure

belongs to the AHA1 family

Compartment

• cytoplasm, endoplasmic reticulum
• may transiently interact with the endoplasmic reticulum

Expression

• expressed in many tissues, including brain, heart, skeletal muscle & kidney
• epressed at lower levels in liver & placenta
• induced by heat shock & treatment with the HSP90 inhibitor 17-demethoxygeldanamycin (17AAG)

More general terms

• other protein

Additional terms

• vesicular stomatitis virus

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10598
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10598
• OMIM: https://mirror.omim.org/entry/608466
• UniProt: http://www.uniprot.org/uniprot/O95433.html