adapter protein CIKS; connection to IKK & SAPK/JNK; TRAF3-interacting protein 2; nuclear factor NF-kappa-B activator 1; ACT1 (TRAF3IP2, C6orf2, C6orf4, C6orf5, C6orf6)

Function

• possivle role activation of both NF-kappa-B via a NF-kappa-B inhibitor kinase (IKK)-dependent mechanism & stress-activated protein kinase (SAPK)/JNK
• interacts with IKBKG/NF-kappa B essential modulator, with CHUK/IKK-alpha & with IKBKB/IKK-beta

Alternative splicing

named isoforms=3

Expression

widely expressed

More general terms

• other protein

Additional terms

• c-jun NH2 terminal kinase, jun kinase (JNK) or stress-activated protein kinase (SAPK)
• IkB kinase complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10758
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10758
• OMIM: https://mirror.omim.org/entry/607043
• UniProt: http://www.uniprot.org/uniprot/O43734.html