osteoclast-stimulating factor 1 (OSTF1)

Function

• induces bone resorption, acting probably through a signaling cascade which results in secretion of factor(s) enhancing osteoclast formation & activity
• interacts with SRC & SMN1

Structure

• the SH3 domain mediates interaction with SMN1
• contains 3 ANK repeats
• contains 1 SH3 domain

Compartment

cytoplasm (probable)

Expression

• ubiquitously expressed
• present in osteoclasts (at protein level)

More general terms

• ankyrin repeat domain protein (ANKRD)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26578
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:26578
• OMIM: https://mirror.omim.org/entry/610180
• UniProt: http://www.uniprot.org/uniprot/Q92882.html